Following her debut with the Canadian Opera Company as Micaela in Carmen, this Canadian-born soprano joined both the New York City and San Francisco Operas. She has also sung with opera companies throughout North America and Europe. Her roles have included Violetta in La Traviata, Alice Ford in Falstaff, Gilda inRigoletto, Nedda in I Pagliacci, the title role in Suor Angelica, Mimì in La Bohème, Juliette in Roméo et Juliette, Elle in La Voix Humaine, and Héro in Béatrice et Bénédict.

As a recitalist she performed internationally under the auspices of the Canadian Government, the Australian Broadcasting Corporation, Les Jeunesses musicales, and the United States Department of State. With orchestra she sang under the batons of Sir Charles Mackerras, Charles Dutoit, Seiji Ozawa, Julius Rudel, and James De Preist. Her recordings include Songs of the Great Opera Composers with Mikael Eliasen, pianist, on the Musical Heritage Society label, as well as releases on the C.B.C. International Series and Vanguard labels.

Miss Patenaude-Yarnell serves on the Voice faculties of Manhattan School of Music and the Curtis Institute of Music.

Her students perform with the Metropolitan Opera, New York City Opera, San Francisco Opera, Royal Opera Covent Garden, Paris Opéra, Chicago Lyric Opera, and Stuttgart Opera and are participants in the young artists programs at Santa Fe Opera, Houston Grand Opera, Seattle Opera, Opera Center (Zurich, Switzerland), and Volksoper (Vienna). Several of her students are current winners of the George London Foundation Awards, Marilyn Horne Foundation Awards, and Puccini Foundation Awards, as well as the Metropolitan Opera National Council Auditions First Prize Winner, 2004.

She has presented her master class "The Principals of Bel Canto" throughout the U.S. and Canada. In the 2014-15 season Miss Patenaude-Yarnell has given master classes in the Art of Bel Canto at the Royal Opera House (Covent Garden) Young Artists Program, Princeton University, and the University of Southern Ontario (Canada). She is presenting classes in spring 2015 at Guild Hall (London, England), the Royal Welsh College of Music/Drama (Cardiff, Wales), and Oberlin in Italy (Arezzo, Italy).